SkinWizard 12% Hydroquinone cream

The lightening formula originally proposed by Dr Kligman remains the most effective treatment for melasma (chloasma). Most doctors mix equal proportions of hydroquinone 4% (the highest strength commercially available), tretinoin 0.05 - 0.1% and a steroid cream. Unfortunately, the final concentration of hydroquinone is only 1.33%, which probably explains its lack of efficacy. SkinWizard's 12% hydroquinone cream overcomes this problem and allows a variety of 4% hydroquinone creams to be formulated.

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The possible forumulae are numerous; below are just some examples:

Modified Kligman formula with steroid
Mix	Final Concetration
1 part 12% hydroquinone	4% hydroquinone
1 part 0.1% tretinoin	0.033% tretinoin
1 part steroid cream (full or reduced strength)	1/3 of the original strength steroid
Modified Kligman formula without steroid
Mix	Final Concentration
1 part 12% hydroquinone	4% hydroquinone
2 parts 0.1% tretinoin	0.067% tretinoin
Hydroquinone cream 4%
Mix	Final Concentration
1 part 12% hydroquinone	4% hydroquinone
2 parts any cream base

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